You can reach Villa Alexandra by car from Nikos Kazantzakis Airport of Heraklion, taking the E75 with direction to Agios Nikolaos.
After about 36klm, turn left, taking the exit towards Sissi.
Continue on this road for about 2klm, and turn left again. After about 1,5 klm you will find the villa on your left hand side.
Total driving time: 40 minutes